Tretinoin, also known as all-trans retinoic acid (ATRA), is medication used for the treatment of acne and acute promyelocytic leukemia. 3 4 5 For acne, it is applied to the skin as a cream or ointment. 5 For leukemia, it is taken by mouth for up to three months. 3 Common side effects when used by mouth include shortness of breath, headache, numbness, depression, skin dryness, itchiness, hair loss, vomiting, muscle pains, and vision changes a-ret gel 0.1 (tretinoin). 3 Other severe side effects include high white blood cell counts and blood clots. 3 When used as a cream, side effects include skin redness, peeling, and sun sensitivity. 5 Use during pregnancy is contraindicated due to the risk of birth defects. 3 1 It is in the retinoid family of medications. 4 Tretinoin was patented in a ret cream dubai, and approved for medical use in 1962. 6 It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. 7 Tretinoin is available as a generic medication. 8 In the United Kingdom the cream together with erythromycin costs the NHS about ?7.05 per 25 mL while the pills are a-ret gel 0.1 (tretinoin)?1.61 per 10 mg. 5 In 2016, it was the 297th most prescribed medication in the United States with more than a million prescriptions. 9 Tretinoin is most commonly used to treat acne. 10 In topical form, this drug is pregnancy category C and should not be used by pregnant women. 10 2 People using the topical form should not also use any cream or lotion that has a strong drying effect, contains alcohol, astringents, spices, lime, sulfur, resorcinol, or aspirin, as these may interact with tretinoin or exacerbate its side effects. 10 Tretinoin is used to induce remission in people with acute promyelocytic leukemia who have a mutation (the t(a ret cream dubai) translocation 160 and/or the presence of the PML/RAR a-ret gel 0.1 (tretinoin)? gene) and who don't respond to anthracyclines or can't take that class of drug. It is not used for maintenance therapy. 11 </ref> 12 13 By mouth, this drug is pregnancy category D and should not be used by pregnant women as it may harm the fetus. 11 1 Topical tretinoin is only for use on skin and it should not be applied to eyes or mucosal tissues. Common side effects include skin irritation, redness, swelling, and blistering. 10 The oral form of the drug has boxed warnings concerning the risks of retinoic acid syndrome and leukocytosis. 11 Other significant side effects include a risk of thrombosis, benign intracranial hypertension in children, high lipids (hypercholesterolemia and/or hypertriglyceridemia), and liver damage a-ret gel 0.1 (tretinoin). 11 There are many significant side effects from this drug that include malaise (66%), shivering (63%), hemorrhage (60%), infections (58%), peripheral edema (52%), pain (37%), chest discomfort (32%), edema (29%), disseminated intravascular coagulation (26%), weight increase (23%), injection site reactions (17%), anorexia (17%), weight decrease (17%), and myalgia (14%).